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Biostir® AD
Code Product Name Volume Price(¥JPY)
※ex-works price
Information More
AD001 Biostir® AD 30 g 260,000 Ointment including mite allergens derived from Dermatophagoides farinae, -30℃  
AD002 15 g 135,000  
AD004 5 g 50,000
Item Method Animal
Atopic Dermatitis Model Services & Pharmacological Tests Induce atopic dermatitis-like lesion in NC/Nga mice with Biostir® AD which has a high content of mite allergens from Dermatophagoides farinae.
Sensitize/immunize mice percutaneously.
Obtain an atopic dermatitis model with a high probability.
Evaluate an efficay of test substances to the disease model.
Evaluation items: symptom score, IgE, histopathology, scratching behavior, etc.
mouse (NC/Nga) Please ask us for more details.

Features

  1. The extract of house dust mites, which are relevant to atopic dermatitis, is one of the ingredients
  2. Biostir® AD is able to induce atopic dermatitis-like skin lesion in NC/Nga mice
  3. The efficacy of both tacrolimus ointment and corticosteroid ointment is observed in this model
  4. Biostir® AD is able to cause dermatitis to NC/Nga mice with a high probability
  5. Biostir® AD will save time and effort until the onset of dermatitis observed when compared to the repeated applications of mite allergen suspension
  6. There are no products with a similar concept

How to use

After barrier disruption with 4 % sodium dodecyl sulfate, apply 100 mg of Biostir® AD on the shaved dorsal skin and both surfaces of each ear two times a week.
Repeat this procedure for 3 weeks. The application is done 6 times in total.

Example

Animal female NC/Nga mice
Clinical aspect for atopic dermatitis-like skin lesion With scratching behavior, erythema, papule, scale, scab, and lichenification on the skin were observed
Histological evaluation The lesional skin showed a significant thickening of the dermis and epidermis, hyperkeratosis, and parakeratosis.
An increased number of dermal inflammatory cells including mast cells and eosinophills were observed in lesional mice.
The number of total and degranulated mast cells in lesional mice was much higher than those in normal mice.
Serum total IgE significantly elevated

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